Vangl2 and planar cell polarity signaling in cardiac development
10.3760/cma.j.issn.1673-4408.2012.06.009
- VernacularTitle:Vangl2及平面细胞极化信号通路在心脏发育中的作用
- Author:
Yuan YUAN
- Publication Type:Journal Article
- Keywords:
Vangl2;
Noncanonical Wnt/PCP pathway;
Cardiac development;
Congenital heart disease
- From:
International Journal of Pediatrics
2012;(6):572-575
- CountryChina
- Language:Chinese
-
Abstract:
Planar cell polarity pathway regulates cell polarity and polarized cell movements.Recent studies in mouse models have found mutations in several genes in this pathway and specifically in the Vangl2 gene,which results in abnormalities in cardiac development,suggesting Vangl2 and this pathway play an important role in heart development.This review mainly elucidates the mechanisms regulated by the Vangl2 gene and PCP pathway during outflow tract development and the formation of the coronary vasculature.
