The role of nuclear factor kappa B and vascular cell adhesion molecule-1 in renal disease
10.3760/cma.j.issn.1673-4408.2013.01.012
- VernacularTitle:核因子-κB和血管细胞黏附分子-1在肾脏疾病中的研究进展
- Author:
Hang YU
- Publication Type:Journal Article
- Keywords:
Nuclear factor kappa B;
Vascular cell adhesion molecule-1;
Kidney disease
- From:
International Journal of Pediatrics
2013;(1):41-44
- CountryChina
- Language:Chinese
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Abstract:
Nuclear factor kappa B (NF-κB) is an important nuclear transcription factor involved in a wide range of inflammatory mediators,adhesion molecules,chemokines and inflammatory-related enzymes in gene regulation,causing immune damage.Vascular cell adhesion molecule-1 (VCAM-1),an adhesion molecule,belongs to the immunoglobulin superfamily and can mediate adhesion of inflammatory cells and endothelial cells caused by inflammatory injury.VCAM-1 gene promoter region contains a series of many of the features of NF-κB site.NF-κB activation can increase the expression of VCAM-1 that causes the immune and inflammatory injury.Present study has found that immune inflammation is the basis of a variety of renal diseases.NF-κB,VCAM-1 in kidney disease and its research progress may be discussed in this article.
