Study on the correlation between the levels of HbA1c,plasma NT-proBNP and the cardiac function in patient with acute coronary syndrome
10.3760/cma.j.issn.1008-6706.2012.23.011
- VernacularTitle:糖化血红蛋白和N末端脑钠肽原与急性冠脉综合征患者心功能的相关性研究
- Author:
Yongsheng SONG
- Publication Type:Journal Article
- Keywords:
Glycosylated hemoglobin;
NT-proBNP;
Acute coronary syndrome;
Type 2 diabetes mellitus;
Cardiac function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;(23):3541-3542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between glycosylated hemoglobin(HbAlc),plasma NTproBNP and the cardiac function in patients with acute coronary syndrome(ACS).Methods 53 patients with both ACS and type 2 diabetes mellitus(T2DM)(T2DM group),67 patients with ACS(ACS group)were selected as the objects.The HbAlc level was detected by immunohistochemical than turbidimetry,and the content of NT-proBNP was detected by electrochemiluminescence method.Results The levels of HbAlc,plasma NT-proBNP of the T2DM group were(9.21±1.23)％,(3.56±1.12)ng/ml,respectively,which were higher than those of ACS group[(5.09±0.67)％,(0.14±0.04)ng/ml](t=6.495,9.277,all P＜0.01);The cardiac function of ACS patients was positively correlated with the levels of HbA1c and plasma NT-proBNP(r=0.517,0.589,all P＜0.01),and there was positive correlation between the levels of HbAlc and plasma NT-proBNP in ACS patients(r=0.431,P＜0.05).Conclusion The HbAlc and NT-proBNP can promote the injury of the cardiac function of ACS patients,and can be used as diagnostic indicators of the injury of the cardiac function of ACS patients.
