Progress in biological functions of encoded proteins in human cytomegalovirus UL/b' region
10.3760/cma.j.issn.1673-4408.2012.06.015
- VernacularTitle:人巨细胞病毒UL/b’区基因编码蛋白生物学功能的研究进展
- Author:
Chang LIU
- Publication Type:Journal Article
- Keywords:
Human cytomegalovirus;
UL/b' region;
UL138 gene;
Latent infection;
Biological function
- From:
International Journal of Pediatrics
2012;(6):591-595
- CountryChina
- Language:Chinese
-
Abstract:
Human cytomegalovirus(HCMV) is a ubiquitous herpesvirus.It is always a serious pathogen in immunosuppressed individuals,and also the most common and harmful agent causing congenital infection and birth defects.Biological functions of the encoded proteins in HCMV UL/b' region,which is deleted in the HCMV laboratory AD169 strain,have been explored in depth in recent years,and the results demonstrate that the proteins have important roles in HCMV virulence,transmission,tropisms and immune escape and so on.UL133-UL138 locus can promote to establish and maintain HCMV latent infections,and pUL1 38 is the first HCMV protein demonstrated to promote infection with the hallmarks of latency in CD34 + hematopoietic progenitor cells (HPC).Therefore,the products expressed by the gene of HCMV UL/b' region are crucial in the course of HCMV infection.This article reviews the genetic structure and biological functions of encoded proteins in HCMV UL/b' region,especially pULl38 which is related with HCMV latent infections.It will be greatly significant to clarify the pathogenesis of HCMV infection.
