Progress of influenza-related host genetic susceptibility

VernacularTitle:流感相关的宿主遗传易患性研究进展
Author: Qiaowei ZHU
Publication Type:Journal Article
Keywords: Influenza; Genetic susceptibility; Single nucleotide polymorphism
From: International Journal of Pediatrics 2013;(1):31-34
CountryChina
Language:Chinese
Abstract: Genetic susceptibility is the characteristic that the organism is vulnerable to a disease caused by hereditary factors.As the knowledge to genetic susceptibility of infectious diseases and human genome research develops,the WHO has suggested it should be prior to study the genetic susceptibility of influenza.The related familial study of influenza patients proposed genetic susceptibility is one of the death risk factors of seasonal and pandemic influenza patients.The animal and clinical studies which were associated with influenza indicated the host genetic factor that affected viral replication might be the major factor to determine the influenza condition and prognosis.The rapid development of genome sequencing technology has provided an opportunity to further clarify the role of host genetic factor in pathogenesis of influenza.As the human genome is diverse ethnically and geographically,to carry out the homogeneous research collaboration will help to reveal the pathogenesis of influenza.