The study of indicative function of pulse pressure and pulse pressure index on early renal damage in patients with hypertension
10.3760/cma.j.issn.1673-4904.2012.31.009
- VernacularTitle:高血压患者脉压及脉压指数对早期肾损害的指示作用研究
- Author:
Rongchang CUI
- Publication Type:Journal Article
- Keywords:
Hypertension;
Early renal damage;
Pulse pressure;
Pulse pressure index
- From:
Chinese Journal of Postgraduates of Medicine
2012;(31):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the indicative function of pulse pressure(PP)and PP index(PPI)on early renal damage in patients with hypertension.Methods Eighty old aged patients with hypertension and renal damage were selected as group A,60 old aged patients with hypertension as group B,and 30 old aged healthy people as group C.PP and PPI were examined in all groups,and early renal damage index was examined in group A.Results The rates of PP ≥ 60 mm Hg(1 mm Hg=0.133 kPa)and PPI ≥0.5 in group A were significantly higher than those in group B and group C[70.0％(56/80)vs.41.7％(25/60)and 26.7％(8/30),75.0％(60/80)vs.43.3％(26/60)and 23.3％(7/30),P＜0.05].In group A,there were significant differences between PP ≥ 60 mm Hg patients and PP＜60 mm Hg patients in beta 2 microglobulin(β 2-MG),microalbuminuria(MAU),high-density lipoprotein(HDL),low-density lipoprotein(LDL)and homocysteine protease inhibitors C(Cys-C)[(13.23±3.22)mg/L vs.(12.03±2.32)mg/L,(56.6±13.2)mg/24 h vs.(42.7±12.3)mg/24 h,(1.9±1.2)mmol/L vs.(2.2±1.3)mmol/L,(2.6±1.2)mmol/L vs.(2.9±1.3)mmol/L,(2.01±0.80)mg/L vs.(1.21±0.90)mg/L,P＜0.05],but there was no significant difference in serum uric acid(SUA)and serum creatinine(SCr)(P＞0.05).There were significant differences between PPI ≥0.5 patients and PPI＜0.5 patients in β 2-MG,SCr,MAU,LDL and Cys-C[(10.53±2.43)mg/L vs.(14.00±2.15)mg/L,(97±22)μmol/L vs.(82±16)μmol/L,(52.5±12.4)mg/24 h vs.(40.7±11.3)mg/24 h,(2.2±1.2)mmol/L vs.(2.7±1.3)mmol/L,(1.91±0.90)mg/L vs.(1.23±1.10)mg/L,P＜0.05],but there was no significant difference in SUA and HDL(P＞0.05).Conclusions The rates of PP ≥ 60 mm Hg and PPI ≥ 0.5 in hypertension with renal damage are significantly higher than those in simple hypertension and healthy people.PP and PPI can be served as the indexes of early renal damage,and it should be cautious on this kind of patients.
