Preoperative TACE on prognosis of patients with hepatocellular carcinoma treated with liver transplantation : a Meta-analysis
10.3760/cma.j.issn.1007-8118.2012.12.010
- VernacularTitle:肝移植术前择期肝动脉化疗栓塞术对肝细胞癌患者预后影响的系统评价
- Author:
Yi ZHOU
;
Jialin ZHANG
;
Yan CUI
;
Le LI
- Publication Type:Journal Article
- Keywords:
Hepatic cancer;
Meta-analysis;
Elective transcatheter arterial chemoembolization;
Liver transplantation
- From:
Chinese Journal of Hepatobiliary Surgery
2012;(12):919-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact on long-term survival using elective transcatheter arterial chemoembolization (TACE) before liver transplantation (LT) to treat patients with hepatocellular carcinoma (HCC).Methods A medical literature search was conducted up to October 2011 to identify comparative studies which evaluated survival rates,recurrence rates,and disease free survival.Pooled odds ratios (OR) and 95 ％ confidence intervals (95 ％ CI) were calculated using either the fixed or random effect model.Results 571 patients were included into this meta-analysis:326 patients were treated with elective TACE before LT and 245 patients were not treated before LT.A comparison between the elective pretransplantation TACE group and the LT only group showed the odds risks (95％CI) of 1-,3-,5-years overall survival rate were 1.90 (0.09-3.33),1.19 (0.67-2.14),1.23(0.63-2.39),respectively.The odds risks (95％CI) of 1,3,5-years disease free survival rates were 1.36 (0.65-2.83),0.91 (0.48-1.75),1.16 (0.76-1.79),respectively.The odds risk (95％CI of recurrence was 1.60 (0.65-3.89).Conclusion Pretransplatation TACE improved 1-year overall survival,but it did not improve the 3 and 5 years overall survival,disease-free survival and recurrence rates.
