Early origins of polycystic ovary syndrome
10.3760/cma.j.issn.1673-4408.2013.01.010
- VernacularTitle:生命早期活动与多囊卵巢综合征
- Author:
Xiaoqin XU
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Prenatal androgen;
Adipose tissue expandability;
Insulin resistance
- From:
International Journal of Pediatrics
2013;(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
The clinical manifestations of polycystic ovary syndrome(PCOS) often emerge during childhood and are related with early life events.Fetal androgen excess may contribute to the etiology of PCOS.Otherwise,fetal growth restriction can confer a setpoint of maximal adipose tissue expansion and may lead to a state of insulin resistance which may finally contribute to the pathophysiology of PCOS.Two hypothesis,the prenatal androgen hypothesis and the adipose tissue expandability hypothesis,have been advanced,and have explained the prenatal origins of PCOS.This paper discusses the relationship between the PCOS and the two hypotheses to demonstrate the PCOS as a fetal origins of adult disease.
