The roles and administration methods of insulin in the early treatment of acute brain injury

VernacularTitle:胰岛素在急性脑损伤早期治疗中的作用和运用方法
Author: Jiang TANG ; Limin ZHOU ; Han JIANG ; Rong LI ; Jianqiang HAN
Publication Type:Journal Article
Keywords: Brain Injuries/therapy; Acute disease; Insulin/therapeutic use
From: Journal of Chinese Physician 2012;(11):1472-1474
CountryChina
Language:Chinese
Abstract: Objective To explore the roles of insulin in the early treatment of acute brain injury and its administration methods.Methods 253 patients were randomly divided into the intensive insulin therapy group and the conventional therapy group.Infection rates,the short-term effect (APACHE Ⅱ assessment),and long-term efficacy (GOS prognosis) was compared between two groups.Results The results of the strengthen treatment group in the rate of infection (25.95％ vs 39.34％,x2 =5.17,P ＜0.05),the short-term effect (11.33 ± 7.66 vs 16.49 ± 14.97,u =3.42,P ＜ 0.05) and the long-term efficacy (40.46％,55.73％,3.82％ vs 25.41％,68.85％,5.74％,x2 =7.62,P ＜0.05) were significantly better than the conventional therapy group with the statistically significant differences (P ＜ 0.05).Conclusions The hypoglycemic effect,neuroprotective effect,regulatory role,and nutrition role of insulin occurred in the early treatment of acute brain injury.After acute brain injury,patients with hyperglycemia should be treated early with an enough volume,continuous,and uniform insulin.