mTOR and glomerular disease
10.3760/cma.j.issn.1673-4408.2012.06.018
- VernacularTitle:mTOR与肾小球疾病
- Author:
Xiaoju ZHOU
- Publication Type:Journal Article
- Keywords:
Mammalian target of rapamycin;
Podocytes;
Nephropathy;
mTOR inhibitor
- From:
International Journal of Pediatrics
2012;(6):602-605
- CountryChina
- Language:Chinese
-
Abstract:
The mammalian target of rapamycin (mTOR)is a evolutionary conserved serine/threonine kinase that catalytics specific substrates and regulates cellular basic physiological events,such as growth,proliferation,autophagy and protein translation.It plays an important role in the regulation of cancer,diabetes and a variety of kidney diseases.Most of glomerular diseases are resulted from the podocytes and filtration barrier damage.Studies have suggested that there is a close relationship between mTOR and podosytes damage,but specific mechanism of regulation is not clear now.This review discusses the regulatory mechanism of mTOR kinase and its role in the glomerular disease to provide new ideas for understanding of glomerular disease pathogenesis.
