Poly ADP-ribose polymerase inhibitors in cancer therapy
10.3760/cma.j.issn.1673-422X.2012.011.012
- VernacularTitle:PARP抑制剂抗肿瘤治疗研究进展
- Author:
Qiang MA
;
Jiqing HAO
- Publication Type:Journal Article
- Keywords:
Poly (ADP-ribose) polymerascs;
Enzyme inhibitors;
DNA damage;
DNA repair enzymes;
Neoplasms
- From:
Journal of International Oncology
2012;(11):837-839
- CountryChina
- Language:Chinese
-
Abstract:
Poly ADP ribose polymerases (PARP) play an important role in DNA damage repair and genome stability.So,PARP inhibitors can inhibit the DNA damage repairing of tumor cells and enhance the sensitivity of the DNA of tumor cells to damage factors.In recent years,PARP inhibitors have been more and more concerned.PARP inhibitors can kill tumor cells with certain genetic mutations alone by synthetic lethal effect.In addition,PARP inhibitors in combination with chemotherapy or radiotherapy can increase the sensi tivity of tumor cells to the chemotherapy or radiotherapy.PARP inhibitors are expected to play an important role in cancer therapy.
