MMP-2 and MMP-9 in malignant tumor
10.3760/cma.j.issn.1673-422X.2012.011.007
- VernacularTitle:MMP-2和MMP-9在恶性肿瘤中的研究进展
- Author:
Mingming ZHANG
;
Yuqing XU
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase 2;
Matrix metalloproteinase 9;
Neoplasms
- From:
Journal of International Oncology
2012;(11):820-823
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are gelatinases of matrix metalloproteinase family,which play a crucial role in the cancer cell growth,differentiation,invasion,migration,the regulation of tumour angiogenesis and immune surveillance because of their ability to degrade extracellular matrix proteins.So they are significantly associated with development and progression of various tumors.In recent years,the inhibitors and drugs against MMP-2 and MMP-9 arouse wide concern.
