Changes of serum adiponectin levels in patients with essential hypertension and the correlation with carotid artery intima-media thickness
10.3760/cma.j.issn.1673-4904.2012.36.006
- VernacularTitle:原发性高血压患者血清脂联素水平的变化及其与颈动脉内膜中层厚度的关系
- Author:
Yang LU
;
Jiyin QIAN
;
Aifang CHEN
- Publication Type:Journal Article
- Keywords:
Hypertension;
Adiponectin;
Carotid arteries;
Intima-media thickness
- From:
Chinese Journal of Postgraduates of Medicine
2012;(36):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum adiponectin (APN) levels in patients with essential hypertension (EH) and the correlation with carotid artery intima-media thickness (IMT).Methods Sixty patients with EH(EH group) and 30 healthy people (control group) were studied,the EH patients were divided into 3 subgroups with 20 cases each according to the standard of China guideline for hypertension prevention and control (2005).The serum APN level was detected by double antibody sandwich ABC enzyme-linked immunosorbent assay,the blood lipids levels [total cholesterol (TC),triglyeride (TG),low density lipoprotein-cholesterol (LDL-C) and highdensity lipoprotein-cholesterol (HDL-C)]were detected by automatic biochemical analyzer,and the carotid artery IMT was detected by color Doppler ultrasonography.Results The serum APN levels and carotid artery IMT in EH group and 1,2,3 subgroup were significant differences compared with those in control group [(3.94 ± 1.28),(5.25 ± 1.69),(4.01 ±1.27),(2.56 ± 0.87) mg/L vs.(7.63 ± 2.50) mg/L; (1.30 ± 0.42),(0.94 ± 0.30),(1.32 ± 0.44),(1.65 ±0.51)mm vs.(0.69 ± 0.22) mm,P ＜ 0.05].The comparison between two subgroups,along with elevated blood pressure levels,APN levels gradually decreased,and carotid artery IMT gradually increased (P ＜0.05).The serum TC,TG,LDL-C and HDL-C levels in EH group and 1,2,3 subgroup were significant differences compared with those in control group [TC:(6.53 ± 2.09),(5.14 ± 1.66),(6.59 ± 2.20),(7.86 ±2.42) mmol/L vs.(4.17 ± 1.32) mmool/L;TG:(2.15 ± 0.69),(1.72 ± 0.55),(2.07 ± 0.69),(2.65 ± 0.82)mmol/L vs.(1.38 ±0.44) mmol/L;LDL-C:(3.78 ± 1.21),(3.12 ± 1.01),(3.74 ± 1.25),(4.48 ± 1.38)mmol/L vs.(2.46 ±0.78) mmol/L;HDL-C:(0.96 ±0.31),(1.39 ±0.45),(0.85 ±0.28),(0.64 ±0.20)mmol/L vs.(1.69 ± 0.54) mmol/L,P ＜ 0.05].The comparison between two subgroups,along with elevated blood pressure levels,TC,TG and LDL-C levels gradually increased,and HDL-C gradually decreased (P ＜0.05).There was negative correlation between the serum APN level and carotid artery IMT (r =-0.435,P＜0.01),and there was correlation between the serum APN level and blood lipids levels (TC,TG,LDL-C and HDL-C) (P ＜ 0.01).Conclusions The APN plays an important role in the occurrence and development of EH,it is closely related to the carotid artery IMT thickening and lipid metabolism disorders.Increasing the lipid-lowering drugs may improve the efficacy of antihypertensive therapy in patients with resistant EH.
