The expression and clinical significance of β tubulin Ⅲ in locally advanced cervical cancer
10.3760/cma.j.issn.1673-4904.2012.36.002
- VernacularTitle:局部晚期宫颈癌中β-微管蛋白Ⅲ的表达及意义
- Author:
Hong XIA
;
Jianhua YI
;
Yan XU
;
Li YANG
;
Guifen CHU
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Tubulin;
Antineoplastic combined chemotherapy protocols;
Immunohistochemistry
- From:
Chinese Journal of Postgraduates of Medicine
2012;(36):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and chnical significance of β tubulin Ⅲ in locally advanced cervical cancer (LACC).Methods The expression of β tubulin Ⅲ in tumor tissue of 47 patients with LACC was detected by immunohistochemical SP method.The relationship between expression of β tubulin Ⅲ and neoadjuvant chemotherapy (NACT) with paclitaxel,clinical data were analyzed retrospectively.Results The response rate of NACT was 72.3％ (34/47).The β tubulin Ⅲ positive expression rate was 72.3％(34/47),(+) expression rate was 40.4％(19/47),(++) expression rate was 12.8％(6/47),(+++) expression rate was 19.1％(9/47).The response rate of NACT in patients with (++) and (+++) expression was significantly lower than that in patients with (-) and (+) expression [46.7％(7/15)vs.84.4％ (27/32),P =0.007].The expression of β tubulin Ⅲ was related to pathological grade (P =0.021),it was not related to pathological type,clinical stage,status of lymph node metastasis (P =0.822,0.336,0.839).Conclusions The NACT of paclitaxel combined with cisplatin is effective to LACC.The abnormality expression of β tubulin Ⅲ in LACC tissue relates to drug resistance of paclitaxel and biological behavior of cervical cancer,it may be an index to predict prognosis of cervical cancer.
