Expression of KLK10 in endometrioid adenocarcinoma and its relationship with ER and PR
10.3760/cma.j.issn.1006-9801.2012.11.010
- VernacularTitle:人类组织激肽释放酶10在子宫内膜腺癌组织中的表达及其与雌激素、孕激素受体表达的相关性
- Author:
Jianfeng NIU
;
Shoucui LAI
;
Shaohua LIU
;
Jingwen XUE
;
Xiangna WAN
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Tissue kallikreins;
Receptors,estrogen;
Receptors,progesterone
- From:
Cancer Research and Clinic
2012;(11):752-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of human kallikrein10 (KLK10) in different endometrioid tissues and analyse the relationship of KLK10 with ER and PR in endometrioid adenoearcinoma.Methods The expression of KLK10 protein in 12 normal endometria,19 endometrial hyperplasia and 34 endometrial carcinoma were detected by immunohistochemistry.The correlations of the expression of KLK10 protein,ER and PR were analyzed.Results The expression of KLK10 in stage Ⅰ,Ⅱ and Ⅲ were 64.3 ％(9/14),30.0 ％ (3/10),10.0 ％ (1/10),and the difference was statistically significant (P ＜ 0.05).The expression of KLK10 in endometrial carcinoma,normal endometria,endometrial hyperplasia were 66.7 ％ (8/12),33.3 ％(4/12),10.0 ％ (1/10),and the difference was statistically significant (P ＜ 0.05).The expression of KLK10 in G1,G2,G3 were 66.7 ％,33.3 ％,10.0 ％,and the difference was statistically significant (P ＜ 0.05).The positive rate of KLK10 expression was 38.2 ％ and the positive rates of ER and PR expression were 67.6 ％and 55.9 ％,respectively,in 34 endometrial carcinoma.The expression of KLK10 was positively correlated with ER and PR expression (x2 =0.448,P ＜ 0.01).Conclusion Absence or down-regulated expression of KLK10 may play an important role in the formation and development of endometrioid adenocarcinoma.The low expression of KLK10 is correlated with low expression of ER and PR in endometrioid adenocarcinoma.The positive expression of KLK00,ER and PR predicts a better prognosis.
