Response of concurrent radiation combined with interventional artery infusion chemotherapy in advanced cervical carcinoma
10.3760/cma.j.issn.1006-9801.2012.11.009
- VernacularTitle:同步放疗联合介入化疗治疗中晚期子宫颈癌的临床观察
- Author:
Liwei SHEN
;
Lili DU
;
Aimin ZHAI
;
Yiping XIAO
;
Chunshan HAN
;
Peng WANG
- Publication Type:Journal Article
- Keywords:
Uterine cervical neoplasms;
Radiotherapy computer assisted;
Chemotherapy,cancer,redgional perfusion
- From:
Cancer Research and Clinic
2012;(11):749-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical curative effects and side effects of concurrent radiotherapy combined with interventional artery infusion chemotherapy in advanced cervical carcinoma.Methods 48 patients with advanced cervical carcinoma were randomly divided into two groups including concurrent radiotherapy combied with interventional artery.infusion ehemotherapy group (25 patients) and radiotherapy group (23 patients).Each patient in the concurrent radiotherapy combined with interventional artery infusion chemotherapy group was given THP,DDP and 5-Fu,repeatedly every 28 days,total 3-4 cycles.Radiotherapy was given at the same time.Results The effective rates of the concurrent radiotherapy combined with interventional artery infusion chemotherapy group and radiotherapy group were 92.0 ％ (23/25)and 69.6 ％ (16/23),respectively.The overall 3 year survival rates for the patients in concurrent radiotherapy eombined with interventional artery infusion chemotherapy group and radiotherapy group were 80.0 ％ (20/25)and 52.2 ％ (12/23),respectively,and there was statistically significant between the 2 groups (all P ＜ 0.05).No more side effects were found in the concurrent radiotherapy combined interventional artery infusion chemotherapy group (P ＞ 0.05).Conclusion Concurrent radiotherapy combined with interventional artery infusion chemotherapy in advanced cervical carcinoma can increase short term therapeutic effect and improve the survival rate of the patients without more side effects.
