Gastrin and miRNA in the development of colorectal neoplasms
10.3760/cma.j.issn.1673-422X.2012.011.018
- VernacularTitle:胃泌素和微小RNA与大肠癌的发生发展
- Author:
Teng CHENG
;
Pei WU
;
Jiading MAO
- Publication Type:Journal Article
- Keywords:
Gastrins;
MicroRNAs;
Colorectal neoplasms
- From:
Journal of International Oncology
2012;(11):857-860
- CountryChina
- Language:Chinese
-
Abstract:
It has been reported that the high expression of gastrins and their receptors promotes some colorectal neoplasms cells proliferation and inhibit apoptosis.MicroRNAs (miRNAs) are closely related to gene expression regulation in colorectal neoplasms.Researches show that miRNAs have multiple intersections in the regulatory network of colorectal neoplasms with the signal transduction pathway of gatrins which controls the proliferation of colorectal neoplasms.Gastrins perhaps control the proliferation of colorectal neoplasms cells through miRNA signal transduction pathways.These findings have greatly expanded the understanding of the pathoge nesis of colorectal neoplasms and will provide new ideas and methods for the diagnosis and treatment of colorectal neoplasms.
