Study on extraction of thyroglobulin from thyroid gland of pig
- Author:
Doan Thanh Hien
- Publication Type:Journal Article
- Keywords:
Thyroglobulin;
Thyroid gland;
Pig;
Extraction
- MeSH:
Thyroglobulin;
Thyroid Gland
- From:Pharmaceutical Journal
2005;348(4):7-10
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
This study related to a process for the production of thyroglobulin from hog thyroid glands. Ground hog thyroid glands were subjected to the saline digestion to produce a thyroglobulin extract. The extract was precipitated by pH adjustment and then heated to a denaturing temperature. The exctract process was designed and was optimized by MODDE 5.0. Using high performance liquid chromatogaphy (HPLC) to measure thyroid hormon concentration in the thyroglobulin. The product had a T4 to T3 ratio is 5. The hormon of the thyroglobulin have got required stability after accelerated test at the temperature of 40 + 2oC and the relative humidity of 75 + 5% for 3 months
