Changes of coagulation function and serum cytokines in patients with bee-sting poisoning

VernacularTitle:蜂蜇伤患者凝血功能和细胞因子水平的变化
Author: Caijuan YUE ; Lei CHEN ; Jingjing WANG
Publication Type:Journal Article
Keywords: Blood coagulation disorders; Bee-sting poisoning
From: Chinese Journal of General Practitioners 2012;(12):939-940
CountryChina
Language:Chinese
Abstract: Fifty-one patients with bee-sting poisoning were divided into slight poisoning group (n =22),moderate poisoning group (n =20) and severe poisoning group (n =9).And 30 healthy persons were selected as control group.The levels of interleukin-8 (IL-8),Von Willebrand factor (vWF),prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB),thrombin time (TT) and D-dimer were measured.The levels of all parameters in slight poisoning group were no significantly different from with control group (P ＞ 0.05).The levels of PT,APTT,IL-8 and vWF were significantly higher in moderate and severe poisoning groups than those in the control group (P ＜0.01).But the levels of APTT,IL-8 and vWF in severe poisoning group were much higher than those in moderate poisoning group (P ＜0.01).The injury of vascular endothelial cell by IL-8 and vWF caused the change of coagulative function and promoted the progress of inflammation.