Correlation analysis of B cell activating factor promotor polymorphism-871 C/T and systemic lupus erythematosus
10.3760/cma.j.issn.1007-7480.2013.02.012
- VernacularTitle:B细胞活化因子启动子-871 C/T基因多态性与系统性红斑狼疮的相关性研究
- Author:
Xiaowei LAI
;
Huiping GONG
;
Xiuzhen SONG
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Polymorphisms,single nucleotide;
B cell activating factor
- From:
Chinese Journal of Rheumatology
2013;(2):124-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study was aimed to detect the correlation of B cell activating factor (BAFF) promotor polymorphism-871 C/T and systemic lupus erythematosus (SLE).Methods BAFF promotor polymorphism-871 C/T was detected by the means of allele specific polymerase chain reaction (ASPCR) and agarose gel electrophoresis in 76 cases of SLE and 80 nonthrombosis normal individuals.The data of genotypic frequency and allele genotypic frequency were analyzed statistically with x2 test between the two groups.Results Fifty-one point two percent of normal individuals exhibited C/C.Thirty-five percent were heterozygous for C/T,and 13.8％ were homozygous for T/T.SLE group exhibited a different distribution pattern (30.3％ C/C,43.4％C/T,26.3％T/T).The allele frequency of T in SLE and normal individuals was 48.0％ and 31.2％ respectively.There was significant difference in the BAFF-871 C/T genotypic frequency between the SLE and nonthrombosis normal individuals (P＜0.05).Conclusion The polymorphism-871 C/T of BAFF promoter is correlated with the pathogenesis of SLE.The gene may be a major susceptible gene for SLE in Chinses Han people.Further investigations may be needed.
