The influence of Apolipoprotein B gene mutations on the lipid-regulating effect of atorvastatin in patients with hyperlipidemia
10.3760/cma.j.issn.1008-6706.2012.23.021
- VernacularTitle:高脂血症患者载脂蛋白B基因突变对阿托伐他汀调脂作用的影响
- Author:
Meiqin YU
- Publication Type:Journal Article
- Keywords:
Hyperlipemia;
Apolipoprotein B;
Gene,mutations;
Atorvastatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;(23):3560-3562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of Apolipoprotein B(ApoB)gene mutations on the lipid-regulating effect of atorvastatin in patients with hyperlipidemia.Methods 152 patients with hyperlipidemia were selected as the research targets,the ApoB gene polymorphism was detected by polymerase chain reaction-restrictive cut inside fragment length polymorphism(PCR-RFLP)method.All the patients given atorvastatin treatment,and determined lipid levels before and after treatment.Then the lipid level[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)]of the different genotypes(no X+carriers and X+carriers)of patients were analyzed.Results The percentage decline of TC and LDL-C of no X+carriers was(28.98±5.21)％,(32.67±7.19)％,respectively,which were higher than those of X+carriers[(18.97±4.01)％ and(26.07±3.45)％](P＜0.05).The percentage decline of TG and increasing of HDL-C of no X+cartiers had no significance difference with those of X+carriers(all P＞0.05).Conclusion ApoB gene mutation influence serum TC and LDL-C levels of hypedipidemia patients,the levels of TC and LDL-C of X+carriers are higher than those of no X+carriers;And the lipid-regulating effect of atorvastatin for X+carriers is more weaker.
