The establishment of pediatric reference intervals for creatine kinase-MB and troponin Ⅰ
10.3760/cma.j.issn.1009-9158.2012.12.019
- VernacularTitle:肌钙蛋白Ⅰ和肌酸激酶同工酶儿童参考区间的建立
- Author:
Huaiyuan LI
;
Limin JIANG
;
Jianxin ZHENG
;
Xuan SUN
;
Qihua FU
- Publication Type:Journal Article
- Keywords:
Troponin Ⅰ;
Creatine kinase;
Isoenzymes;
Reference values;
Child
- From:
Chinese Journal of Laboratory Medicine
2012;(12):1142-1145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the pediatric reference intervals for Troponin Ⅰ and Creatine kinase-MB (CK-MB).Methods Healthy children (223 boys and 162 girls) aged from 7 months to 12 years old were studied.Blood specimens were collected and centrifuged,all serum samples were kept refrigerated below-70 ℃.Troponin Ⅰ and CK-MB were measured on the UniCel DxI 800 immunoassay system (Beckman Coulter) on the same day.Nonparametric statistics was used to estimate the 99th percentile reference intervals.Results The children were divided into three groups (group A 128 cases; group B 128 cases;group C 129 cases) according to age.The upper reference limits for CK-MB were dependent of age,and the group A (7 months-1 years) was shown to be 13.41 μg/L,the group B (2-3 years) was shown to be 9.35 μg/L,the group C (4-12 years) was shown to be 5.48 μg/L.The upper reference limit for Troponin Ⅰ was independent of age or gender and shown to be 0.01 μg/L among 385 children.Conclusions Pediatric reference intervals for Troponin Ⅰ and CK-MB have been defined in healthy children at a relevant age group (7 months-12 years).It is effective for clinical diagnosis and treatment of myocardial damage for children by determining reference intervals for Troponin Ⅰ and CK-MB.
