Advancement on the pharmacogenomics of immunosuppressant
10.3760/cma.j.issn.1009-9158.2012.11.005
- VernacularTitle:免疫抑制剂的药物基因组学研究进展
- Author:
Yun LIAO
;
Yi LI
;
Bei CAI
;
Lanlan WANG
- Publication Type:Journal Article
- Keywords:
Immunosuppressive agents;
Pharmacogenomics;
Tacrolimus;
Sirolimus
- From:
Chinese Journal of Laboratory Medicine
2012;(11):978-985
- CountryChina
- Language:Chinese
-
Abstract:
At present,transplantation has been the predominant way to solve most of the end-stage diseases,ensued by the use of immunosuppressive drugs.Since the immunosuppressive drugs have narrow therapeutic index,the blood drug concentration is needed to mornior.Pharmacogenetics is one subject which focuses on the interaction between gene and the metabolism of the drug,providing great help for designing the regime of achieving the target drug concentration.Meanwhile,it facilitates the realization of individual therapy.This review thus focuses on the latest advancement on the pharmacogenetics of those immunosupprressants,hoping to provide help for the treatment.
