Progress in the detection of Kras, EGFR, BRAF mutations and its clinical application
10.3760/cma.j.issn.1009-9158.2012.11.004
- VernacularTitle:Kras、EGFR、BRAF基因突变检测及其应用研究进展
- Author:
Yanli SUN
;
Jinming LI
- Publication Type:Journal Article
- Keywords:
Proto-oncogene proteins;
Ras proteins;
Receptor,epidermal growth factor;
Personalized medicine;
Mutation
- From:
Chinese Journal of Laboratory Medicine
2012;(11):971-977
- CountryChina
- Language:Chinese
-
Abstract:
Since a number of genes have been discovered,which are associated with the effect of drug therapy,the development of personalized medicine is enhanced.Meanwhile,personalized test played an important role in choosing proper medicine.Herein,the status of detection of V-ki-ras2 Kirsten rat sarcoma viral oncogene homolog(Kras),epidermal growth factor receptor(EGFR),B-Raf and v-Raf murine sarcoma viral oncogene homolog B1(BRAF) mutation is concluded,moreover,the association between the mutation test and the effect of cancer therapy is summarized.