Pharmacogenomics and individual therapy of immunosuppressive drugs in transplant recipients
10.3760/cma.j.issn.1009-9158.2012.11.003
- VernacularTitle:器官移植受者免疫抑制药物的个体化治疗与药物基因组学研究
- Author:
Lanlan WANG
- Publication Type:Journal Article
- Keywords:
Organ transplantation;
Immunosuppressive agents;
Treatment drug monitoring;
Pharmacogenomics
- From:
Chinese Journal of Laboratory Medicine
2012;(11):967-970
- CountryChina
- Language:Chinese
-
Abstract:
Long-term using of immunosuppressants is necessary to prolong the lifetime of transplanted organ and transplant recipients after transplantation.Due to the great variation in metabolism of immunosuppressive drug,there is the close correlation between drug concentration and rejection or organ injury induced by immunosuppressants.The gene polymorphism of multidrug resistance protein (MDR) and cytochrome P450 isoenzyme (CYP450) could lead to the difference of expression or activation of corresponding coded proteins.Individual gene polymorphism causes not only some special drug metabolism difference,but the huge diversity of the distribution of drug metabolism and drug target function.Except for the clinical therapeutic drug monitoring,detecting hereditary variation and gene polymorphism,analyzing the significance of individual gene polymorphism in drug effect and toxicity,applying individual treatment in clinical treatment research,will be the new mission and challenge for the clinical laboratory technologists.
