An important subject in stem cells research: the regulatory of retinoblastoma pathway for stem cells

VernacularTitle:干细胞应用研究的重要课题:视网膜母细胞瘤基因通路对干细胞的调控
Author: Yi ZHOU ; Yilin WANG ; Danian CHEN
Publication Type:Journal Article
Keywords: Retinoblastoma; Signal transduction/pathophysiology; Stem cells/pathophysiology; Editorial
From: Chinese Journal of Ocular Fundus Diseases 2012;(6):549-551
CountryChina
Language:Chinese
Abstract: Stem cells are crucial for embryonic development and in the maintenance of adult cellular homeostasis.Understanding the regulatory network of stem cells,including embryonic and adult stem cells,will allow us to learn the pathogenesis and possibly design novel approaches to treat many diseases (such as cancer and degeneration).The retinoblastoma (Rb) pathway controls cellular proliferation,differentiation and death.More and more evidences support an important role of Rb activity in the biology of stem and progenitor cells.Transiently inactivating Rb pathway might favor the expanding of functional stem cell populations,thus have values in the future stem cell applications.