A retrospective study of surgical treatment for stage Ⅰ pure bronchioloalveolar carcinoma comparison with adenocarcinoma of the lung
10.3760/cma.j.issn.1001-4497.2012.12.006
- VernacularTitle:Ⅰ期支气管肺泡细胞癌与肺腺癌外科治疗
- Author:
Liang BU
;
Jun LIU
;
Yun LI
;
Hui ZHAO
;
Jun WANG
- Publication Type:Journal Article
- Keywords:
Adenocarcinoma,bronchiolo alveolar;
Thoracic surgery,video-assisted;
Lung neoplasms;
Adenocacinoma;
Pneumonectormy
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2012;(12):725-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the difference between stage Ⅰ pure bronchioloalveolar carcinoma (BAC) and stage Ⅰ adenocarcinoma of the lung among operative cases.Methods We use the Lobectomy Cases Registration and Statistics System database (2006-2011) to compare the epidemiology,clinical presentation,image characteristics,surgical outcomes,recurrence and overall survival between BAC and adenocarcinoma groups.All the patients received lobectomy procedure in the department of thoracic surgery of Peking University People' s Hospital.Results Excluding those cases with both BAC and adenocarcinoma aspects,337 patients were enrolled.Thirty-nine patients were stage Ⅰ pure BAC and 298 patients were stage Ⅰadenocarcinoma.BAC has its proper clinical spectrum,occurring more frequently in women (69.2％ vs.52.0％,P =0.042)and in younger patients (57.4 vs.61.8,P =0.014).BAC also seems to be less dependent on tobacco exposure (12.8％ vs.29.9％,P =0.026).The percentage of ground-glass opacity (GGO) in CT scan of BAC patients was much more than that registered in adenocarcinoma patients (35.9％ vs.9.7％,P ＜0.001).And the tumor size of BAC group was smaller than that of the adenocarcinoma group (1.4 cm vs.2.3 cm,P ＜0.001).The operation method,time,blood loss and complications were similar between the two groups.Kaplan-Meier survival curves showed that both 3-year disease-free survival (DFS) and overall survival (OS) were significantly higher in patients affected by BAC (100％ vs.76.1％,P =0.030 and 100％ vs.86.1％,P =0.041).Conclusion BAC presents specificity in its epidemical,clinical,radiological and evolutionary aspects.Stage Ⅰ pure BAC patients have better prognosis following video-assisted thoracoscopic lobectomy and system lymph node dissection than the similar stage adenocarcinoma patients.
