Expression and prognostic value of TTF-1 of stage Ⅰ non-small cell lung cancer
10.3760/cma.j.issn.1001-4497.2012.11.008
- VernacularTitle:TTF-1在Ⅰ期非小细胞肺癌中的表达与预后
- Author:
Xiaoxiao GE
;
Jicheng TANTAI
;
Youru LIU
;
Heng ZHAO
;
Liyan JIANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Immunohistochemistry;
TTF-1;
Prognosis
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2012;(11):662-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of thyroid transcription factor-1 (TTF-1) in stage Ⅰ non-small cell lung cancer (NSCLC) after operation and to 1 investigate the values in identification of the prognosis of stage Ⅰ NSCLC.Methods The expression of TTF-1 in 129 specimens of stage Ⅰ NSCLC was detected by immunohistochemistry.Results The positive rate of TTF-1 in stage Ⅰ NSCLC was 64.3％.There were significant differences in TTF-1 expression rate among pathological subtypes (x2 =25.231,P ＜ 0.001),different ages (x2 =4.581,P =0.032),sex (x2 =4.900,P =0.027) and differentiation degrees(x2 =11.519,P =0.019).Univariate analysis suggested that in the stage Ⅰ NSCLC patients,the median disease-free survival and overall survival of those positive for TTF-1 expression were superior to those negative:38.9 months versus 27.8 months (P =0.023) and 64.10 months versus 50.68months (P =0.013).Cox regression analysis suggested that TTF-1 expression,tumor differentiation degrees were independent factors affecting the prognosis of stage Ⅰ NSCLC.Conclusion Patients with TTF-1 positive expression often had better survival.Positive expression of TTF-1 and differentiation degree of tumor were independent prognostic factors to affect the prognosis of NSCLC.
