Endoscopic submucosal dissection for upper gastrointestinal neuroendocrine neoplasms
10.3760/cma.j.issn.1007-5232.2012.12.006
- VernacularTitle:内镜黏膜下剥离术治疗上消化道神经内分泌肿瘤的临床价值
- Author:
Xiaoyun WANG
;
Meidong XU
;
Pinghong ZHOU
;
Liqing YAO
;
Yunshi ZHONG
;
Weifeng CHEN
;
Yiqun ZHANG
;
Lili MA
- Publication Type:Journal Article
- Keywords:
Digestive tract;
Neuroendocrine neoplasm;
Endoscopic submucosal dissection
- From:
Chinese Journal of Digestive Endoscopy
2012;(12):679-683
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect and safety of endoscopic submucosal dissection (ESD) for upper gastrointestinal neuroendocrine neoplasms.Methods A total of 19 lesions diagnosed as neuroendocrine neoplasm were treated by ESD.Pathological diagnosis was performed.Adverse eventss were recorded.Patients were followed up for recurrence and metastasis.Results Lesions,0.4-1.5 cm (mean 0.9 cm) in diameter,were all resected at one ESD procedure.The operation time was 15-50 min (mean 20 min).No mass bleeding or perforation occurred.18 cases were histologically diagnosed as neuroendocrine tumors,with 16 as G1 and 2 as G2.One lesion was confirmed as G3 neuroendocrine carcinoma and the patient was referred for extensive surgery.All resected samples were free of residual tumor cell in the lateral and basal margins.Postoperative bleeding occurred in one case and was controlled endoscopically.No recurrence was detected during a mean follow-up of 28 months.Conclusion ESD,as a novel procedure for the treatment of the upper gastrointestinal neuroendocrine neoplasm,is safe and efficacious in clinic.
