EUS-guided celiac ganglion irradiation with iodine-125 seeds for pain control in pancreatic carcinoma: a prospective pilot study
10.3760/cma.j.issn.1007-5232.2012.12.002
- VernacularTitle:内镜超声引导下125I粒子腹腔神经节植入术治疗晚期胰腺癌腹痛的初步研究
- Author:
Kaixuan WANG
;
Zhendong JIN
;
Dong WANG
;
Xianbao ZHAN
;
Yan LIU
;
Zhaoshen LI
;
Huagao ZHANG
- Publication Type:Journal Article
- Keywords:
Endoscopic ultrasonography;
Iodine radioisotopes;
Brachytherapy;
Pancreatic cancer;
Pain
- From:
Chinese Journal of Digestive Endoscopy
2012;(12):665-668
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of direct celiac ganglion irradiation with 125I seeds for pain relief secondary to advanced pancreatic carcinoma (PC).Methods This study enrolled 23 consecutive patients who had moderate to severe pain resulting from advanced PC.All patients underwent EUS-guided direct celiac ganglion irradiation with 125I seeds.Follow-up was conducted at least once weekly until death.Blood parameters,Visual Analog Scale (VAS) score,mean analgesic consumption,and complications were evaluated during follow-up.Results All patients successfully underwent implantation at one attempt.The mean number of seeds implanted in the celiac ganglion per patient was 4 (range 2-6).Immediately after the procedure,pain relief and analgesic consumption showed no significant changes compared with preoperative values.Six patients (26％) reported pain exacerbation.Two weeks later,the VAS score and mean analgesic consumption were significantly less than preoperative values.No procedure-related deaths or major complications occurred.Conclusion EUS-guided direct celiac ganglion irradiation with 125I seeds can reduce the VAS score and analgesic drug consumption in patients with unresectable PC.
