Molecular characteristics of the hemagglutinin and neuraminidase of influenza B viruses isolated in Jiangsu province, 2011
10.3760/cma.j.issn.0254-5101.2012.12.007
- VernacularTitle:江苏省2011年乙型流感病毒血凝素和神经氨酸酶分子流行特征
- Author:
Wei LI
;
Pengfei LUO
;
Fei DENG
;
Yuanfang QIN
;
Hairong ZI
;
Fenyang TANG
;
Xian QI
;
Pingmin WEI
- Publication Type:Journal Article
- Keywords:
Influenza B;
Hemagglutinin;
Neuraminidase;
Molecular characteristics
- From:Chinese Journal of Microbiology and Immunology
2012;(12):1026-1033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To characterize the molecular characteristics of hemagglutinin (HA) and neuraminidase (NA) of influenza B viruses isolated in Jiangsu province,2011.Methods Thirteen strains of influenza B virus in different areas and epidemic period in Jiangsu province,2011 were selected for whole-genome sequencing,and analysis of molecule epidemic characteristics for HA and NA was carried out by bioinformatics method.Results Of the 13 randomly selected influeuza B strains,10 strains were assorted to Victoria lineage strains with NA genes from Yamagata lineage,and 3 strains belong to Yamagata lineage.Compared nucleotide and amino acid sequences of HA and NA genes with their vaccine strains respectiuely,196/197 glycosylation site appeared on HA1 gene in Yamagata/Victoria isolates virus.Conclusion Both B/Victoria and B/Yamagata lineage viruses co-circulated in Jiangsu province,and reassortant virus of Victoria lineage were predominant virus.
