The effects of JNK1 on the responses of cytolytic T cells against viral infection

VernacularTitle:c-Jun氨基末端激酶1对杀伤性T细胞抗病毒效应的影响
Author: Yongqin WANG ; Limei ZHAO ; Qingyu XU ; Pengpeng WANG ; Yang WANG
Publication Type:Journal Article
Keywords: Immune response; Immune regulation; c-jun NH2-terminal kinase; Cytolytic T lymphocyte; Virus infection
From: Chinese Journal of Microbiology and Immunology 2012;(12):1020-1025
CountryChina
Language:Chinese
Abstract: Objective To examine the role of c-Jun NH2-terminal kinase(JNK) 1 in cytolytic T lymphocyte (CTL) responses against virus infection.Methods Wild-type (WT) and JNK1-knockout (JNK1-/-) mice were infected with ectromelia virus(ECTV) through hind footpads.Survival and virus titers in the target organs (liver and spleen) were analyzed.Effector T cells in the spleen and popliteal lymph nodes were determined on day 3 and 7 post-infection.Proliferation and INF-γ production of CTL were also detected.Results JNK1 deficiency caused an increased susceptibility to ECTV infection in mice,indicated by higher case fatality and viral burden in target organs.The decrease in CTL response correlated with a defect in CTL proliferation and INF-γproduction.Conclusion The data suggest that JNK1 is involved in expansion of activated CTL during ECTV infection,and plays an important antiviral role in regulating the proliferation and effector function of CTL.