Treating Parkinson's disease with high and low frequency repetitive transcranial magnetic stimulation: a clinical study

VernacularTitle:高频及低频重复经颅磁刺激治疗不同类型帕金森病的疗效观察
Author: Xiuqin ZHENG ; Suwen YU ; Shengdong CHEN ; Jianbo JIANG
Publication Type:Journal Article
Keywords: Parkinson's disease; Transcranial magnetic stimulation; Motor evoked potentials
From: Chinese Journal of Physical Medicine and Rehabilitation 2012;(12):907-910
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic effects of repeated transcranial magnetic stimulation (rTMS) at high and low frequency for the rigidity and tremors of Parkinson's disease (PD).Methods Sixty-nine patients with PD received rTMS at 5 Hz or 0.5 Hz.The efficacy was assessed using the unified Parkinson's disease rating scale (UPDRS),motor function tests and motor evoked potentials (MEPs).Results Thirty-two patients with rigidity from PD received 5 Hz rTMS therapy,and their UPDRS total scores decreased significantly.Their motor function test results improved significantly and their MEP relaxed motor thresholds were significantly elevated.Thirtyseven patients with tremors from PD received 0.5 Hz rTMS therapy,and their UPDRS total scores were significantly decreased.Their motor function test results improved significantly and their MEP relaxed motor thresholds were significantly elevated.Conclusion High frequency rTMS may improve the symptoms of patients with PD rigidity and low frequency rTMS may improve the symptoms of patients with PD tremors.