Diagnosis and treatment of post-transplant lymphoproliferative disease after hematopoietic stem cell transplantation: Report of one case and literature review
10.3760/cma.j.issn.0254-1785.2013.02.008
- VernacularTitle:异基因造血干细胞移植后淋巴组织增殖性疾病一例并文献复习
- Author:
Xiaoqiong TANG
;
Lin LIU
;
Xiaohua LUO
;
Jianbin CHEN
;
Li YANG
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Lymphoproliferative diseases;
Diagnosis;
Therapy
- From:
Chinese Journal of Organ Transplantation
2013;(2):97-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnosis and treatment of post-transplant lymphoproliferative disease (PTLD) after hematopoietic stem cell transplantation (HSCT).Methods Clinical data of one case of PTLD,including clinical manifestations,diagnosis and treatment,were retrospectively analyzed.And the related literatures were reviewed.Results From January 2007 to November 2012,one case developed PTLD among 196 patients who were followed up after HSCT in the First Affiliated Hospital of Chongqing Medical University.The incidence of PTLD was 0.5％.Clinical manifestations of the patient were not typical,including frequent fever,multiple lymphadenopathy and multiple pulmonary nodules.The patient was diagnosed as diffuse large B-cell lymphoma (B-DLCL) by pathological examination of the swollen lymph node.After withdrawal of immunosuppressants,the temperature returned to normal,and lymphadenopathy and pulmonary nodules disappeared completely.Conclusion PTLD is a severe complication of HSCT with distinctive morphologic and clinical characteristics.The origin of this disease may be associated with Epstein-Barr virus infection and imrnunosuppressive therapy.It needs the pathologic detection to make a definite diagnosis.Several different treatment strategies have been employed,and reduction of immunosuppressive therapy may lead to regression of PTLD.
