Rosiglitazone reduces renal interstitial fibrosis in chronic cyclosporine nephropathy rats
10.3760/cma.j.issn.1001-7097.2012.08.006
- VernacularTitle:罗格列酮对慢性环孢素肾病大鼠肾间质纤维化的保护作用
- Author:
Genyang CHENG
;
Haijian LI
;
Zhangsuo LIU
;
Lin TANG
;
Songxia QUAN
- Publication Type:Journal Article
- Keywords:
Cyclosporine;
Fibrosis;
Rosiglitazone
- From:
Chinese Journal of Nephrology
2012;28(8):611-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of rosiglitazone on renal interstitial fibrosis in chronic cyclosporine nephropathy (CCN) rats.Methods Twenty-eight rats were randomly assigned to control group,rosiglitazone (RGZ,5 mg·kg-1·d-1) group,cyclosporine A(CsA,15 mg·kg-1·d-1) group,rosiglitazone (5 mg·kg-1·d-1) +CsA group.Real-time PCR and RT-PCR methods were used to investigate the expressions of OPN,RANTES on the 14th day and MMP-9,TIMP-1 on the 35th day in kidney of CCN respectively.Results In comparison with control group,the expressions of OPN,RANTES,MMP-9,TIMP-1 in CsA and RGZ+CsA groups were increased (P＜0.05).In comparison with the CsA group,the expressions of OPN,RANTES,MMP-9,TIMP-1 in CsA+RGZ group significantly decreased (P＜0.05).Conclusion Rosiglitazone may protect renal tissue after CCN by decreasing expressions of OPN,RANTES,MMP-9,TIPM-1.
