Hydrotalcite combined with proton pump inhibitor in treatment of post endoscopic submucosal dissection ulcer: a randomized, controlled clinical trial
10.3760/cma.j.issn.1007-5232.2012.08.005
- VernacularTitle:铝碳酸镁联合质子泵抑制剂治疗内镜黏膜下剥离术后人造溃疡的随机对照研究
- Author:
Guotao LU
;
Zhigang YAN
;
Dacheng WU
;
Bin DENG
;
Haiyan CHEN
;
Xuefeng GAO
;
Mingquan YAN
;
Yanbing DING
- Publication Type:Journal Article
- Keywords:
Ulcer,artificial;
Endoscopic submucosal dissection;
Hydrotalcite;
Proton pump inhibitor
- From:
Chinese Journal of Digestive Endoscopy
2012;29(8):433-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic efficacy of a combination of proton pump inhibitor(PPI) and hydrotalcite for endoscopic submucosal dissection (ESD) induced ulcer.Methods Eightyone consecutive patients who underwent ESD were randomly assigned to either the group of PPI and hydrotalcite therapy ( drug combination group,n =41 ) or the PPI group ( n =40).Delayed bleeding rates were monitored and compared.The main upper abdomen symptoms 1-wk later and ulcer healing rates and ulcer diameter 4-wk later were compared between the two groups.Results There was no significant difference in delayed bleeding rate (P ＞ 0.05 ).At the end of first week after ESD,the combination therapy was significantly more effective than the PPI alone in reducing frequencies and severity of upper abdominal pain and upper abdominal distention,while there was no significant difference between the two groups in relieving belch and nausea.A better ulcer healing rates and a smaller ulcer diameter were observed in the combination group at the end of 4 weeks ( P ＜ 0.05 ).Conclusion The combination therapy of hydrotalcite and PPI can relieve upper abdominal symptoms and improve the healing rate of ESD induced ulcer.
