Could serum cystatin C be employed in diagnosing contrast-induced nephropathy after nonemergency endovascular therapy with peripheral arterial diseases?
10.3760/cma.j.issn.1001-7097.2012.07.008
- VernacularTitle:血清胱蛋白酶抑制剂C能用于周围动脉疾病腔内治疗术后造影剂肾病的诊断吗?
- Author:
Yanjiao YANG
;
Xiao TANG
;
Ying ZHOU
;
Yin ZHENG
;
Yingying CHEN
;
Daqiao GUO
;
Feng DING
- Publication Type:Journal Article
- Keywords:
Contrast media;
Risk factors;
Serum cystatin C;
Contrast-induced nephropathy;
Endovascular therapy
- From:
Chinese Journal of Nephrology
2012;28(7):538-543
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the risk factors for contrast-induced nephropathy (CIN) after endovascular therapy in patients with peripheral arterial diseases and to evaluate the conformance of serum cystatin C (Cys C) and serum creatinine in diagnosis of CIN. Methods In this prospective,single center study,in-hospital patients with peripheral arterial diseases undergoing non-emergency endovascular therapy from July 2010 to April 2011 in our hospital were enrolled.CIN was defined asScr increase ≥25％ after angiography.General clinical characteristics and blood biochemical parameters were compared between the non-CIN and CIN groups.Logistic regression analysis was performed to determine risk factors.Changes compared to baseline level in serum creatinine and Cys C at predefined time-points were evaluated.Results A total of 367 patients were enrolled in the study.The proportions of patients with diabetes mellims and treatment with diuretics before angiography,contrast-media dosage were significantly higher in the CIN group than those in non-CIN group (P＜0.05,＜0.01,＜0.01).Logistic regression analysis indicated that diabetes mellitus,contrast-media dosage were risk factors for CIN.Several serum Cys C increase criteria at 24 hours after contrast media exposure all had low sensitivity for predicting a Scr increase ≥25％.Only small overlapped regions were found in Venn diagram between several increasing criteria according to serum Cys C and serum creatinine criterion. Conclusions Diabetes mellitus,contrast-media dosage are independent risk factors for CIN.The results of several increasing criteria according to serum Cys C in evaluating contrast-induced AKI are not coincident well with that of serum creatinine criterion.
