Clinical and neuroimaging analysis of 4 patients with corticobasal degeneration syndrome

VernacularTitle:皮质基底节变性综合征四例临床及影像学分析
Author: Meiyun ZHANG ; Benshu ZHANG ; Ying WANG ; Shuo GAO
Publication Type:Journal Article
Keywords: Basal ganglia; Cerebral cortex; Diagnostic imaging
From: Chinese Journal of Neurology 2012;45(8):595-599
CountryChina
Language:Chinese
Abstract: Objective To investigate clinical and imaging features of corticobasal degeneration syndrome (CBDS). MethodsA clinical, imaging and therapeutic analysis of 4 cases of clinically diagnosed with corticobasal degeneration was conducted. Results Asymmetric parkinsonism was the first symptom in all 4 cases who lacked of response to levodopa. Other symptoms including limb apraxia and anarthria occurred in all 4 cases,myoclonus occurred in three,dementia occurred in two,and involuntary movement occurred in one. All the patients had asymmetric frontoparietal cortical atrophy in the contralateral to the dominantly affected limbs on MRI.Asymmetric hypometabolism of the frontoparietal cortex and basal ganglia was observed on 18 F-FDG PET in all 4 cases.ConclusionsThe clinical features of CBDS are asymmetric parkinsonism,dementia,apraxia,anarthria,myoclonus,and involuntary movement.Brain MRI and 18 F-FDG PET are helpful to diagnosis of CBDS.There is no effective treatment for CBDS at this time.