Research progress on tumor suppressor gene PTEN in gastric carcinoma
10.3760/cma.j.issn.1006-9801.2012.07.024
- VernacularTitle:抑癌基因PTEN在胃癌中的研究进展
- Author:
Fangming GONG
- Publication Type:Journal Article
- Keywords:
Stomach pcveoplasms;
PTEN;
Tumor suppressor gene
- From:
Cancer Research and Clinic
2012;24(7):495-497
- CountryChina
- Language:Chinese
-
Abstract:
PTEN is a tumor suppressor with double specific phosphatase activity,and PTEN brings into its lipid and protein phosphatase activity through PIP3, FAK, MAPK pathway. PTEN also induces apoptosis, inhibits cell growth, and regulates cell migration and adhesiveness. PTEN expression is lower in gastric carcinoma. It may be valuable to evaluate that the abnormal expression of suppressor gene PTEN participates in the malignant conversion process of the gastric mucosa cell, and the expression levels of the PTEN protein can be used to evaluate the pathologic biology behavior of gastric carcinoma.
