An analysis on 200 randomized clinical isolates of Mycobacterium in Sichuan
10.3760/cma.j.issn.0254-5101.2012.06.014
- VernacularTitle:四川地区200例随机临床分枝杆菌分离株耐药状况的分析研究
- Author:
Yuanhong XU
;
Zhenling CUI
;
Zhongyi HU
;
Jianlan HE
;
Mei LUO
;
Yi YUE
;
Ma ZHU
;
Fan ZHU
;
Tao LUO
;
Jing ZHONG
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
Minimum inhibitory concentration (MIC);
Roche absolute concentration method;
Drug susceptibility test;
Multi-drug resistant tuberculosis
- From:
Chinese Journal of Microbiology and Immunology
2012;32(6):555-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the resistant situation and drug of Mycobacteria patients in Sichuan and offer foundation for clinical.Methods Two hundred randomized clinical isolates of Mycobacterium were determined by Roche drug sensitivity and minimum inhibitory concentration (MIC) method.Results Of the 200 clinical isolates,192 stains were Mycobacterium tuberculosis(MTB) (96.0％),8 strains (4.0％) were non-tuberculosis mycobacterium(NTM).Of the 192 MTB strains,108( 57.3％ ) sensitive strains and 84 (43.7％)stains were resistant to one or more than one drugs.Among these 84 resistant strains 23 were multi-drug resistant ( MDR,12.0％ ),4 were extensively drug resistant( XDR,2.1％ ).The anti-TB drug resistance rates were:SM(16.7％),INH(20.8％),RFP(17.2％),EMB(10.9％),PI(16.1％),LFX(8.8％),AMK ( 16.7％ ),CPM ( 6.2％ ),PTA ( 33.3％ ),respectively.Conclusion The resistance rate of tuberculosis keeps at a high level in Sichuan,especially the resistance rate of multiple (≥4) drug,we should oar attention.
