Expressions of leptin and lipoprotein α in esophageal squamous cell carcinoma and their clinical significance

VernacularTitle:瘦素、脂蛋白α在食管鳞状细胞癌中的表达及其临床意义
Author: Shuangping ZHANG ; Shanbing WANG ; Yun CHEN ; Chunli WANG ; Yuming JIA ; Xia ZHANG
Publication Type:Journal Article
Keywords: Esophageal neoplasms; Carcinoma,spuamous cell; Lipids; Leptin
From: Cancer Research and Clinic 2012;24(7):440-443
CountryChina
Language:Chinese
Abstract: Objectiveto investigate serum leptin concentration and lipdid levels in patients with esophageal squamous cell carcinoma and their clinical significance. MethodsBlood samples were collected from 47 patients with esophageal cancer, 20 healthy control subjects. Serum leptin was measured by ELISA and serum lipids was measured by biochemistry auto-analyzer. ResultsThe serum leptin concentration and LP α levels in patients group were significantly higher than those in control group[(13.09±5.94) ng/ml vs (7.584±4.15) ng/ml,(216.50±752.52) ng/ml vs(87.85±10.73) mg/L](P=0.001).However,the TG concentration was significantly lower than control group [(1.23±0.46) mmol/L vs (1.58±0.07) mmol/L]( P=0.001 ).Multiple logistic regression analysis revealed statistically significant association between serum leptin levels and esophageal squamous cell carcinoma incident(ORLeptm =1.442,95％ CI 1.094-1.848). ConclusionThe increased serum leptin levels maybe the risk factors of esophageal cancer,elevated LP α levels in patients might be a compensatory reactions.