The research on the immuno-modulatory abilities of myelodysplastic syndromes patients bone marrow derived mesenchymal stem cells
10.3760/cma.j.issn.0254-5101.2012.05.014
- VernacularTitle:骨髓异常增生综合征患者骨髓来源的间充质干细胞免疫功能异常
- Author:
Xishan ZHU
;
Wei SHI
;
Hongmei ZHANG
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndromes;
Bone marrow derived mesenchymal stem cell;
Immunomodulatory
- From:
Chinese Journal of Microbiology and Immunology
2012;32(5):449-454
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate that whether the immuno-modulatory capacity is intact in myelodysplastic syndrome-refractory anemia (MDS-RA) derived mesenchymal stem cell (MSCs) and what are the differences compare with those from normal donors.Methods Isolating MSC from MDS and normal donors respectively and exam their differences on T lymphocyte activation,proliferation and suppression.Results The results showed that the capacity of suppressing T cell proliferation and activation is weakened.Conclusion We propose that MSCs from pathological environment might be abnormal and should not be used for autologous transplantation.