The research on the immuno-modulatory abilities of myelodysplastic syndromes patients bone marrow derived mesenchymal stem cells

VernacularTitle:骨髓异常增生综合征患者骨髓来源的间充质干细胞免疫功能异常
Author: Xishan ZHU ; Wei SHI ; Hongmei ZHANG
Publication Type:Journal Article
Keywords: Myelodysplastic syndromes; Bone marrow derived mesenchymal stem cell; Immunomodulatory
From: Chinese Journal of Microbiology and Immunology 2012;32(5):449-454
CountryChina
Language:Chinese
Abstract: Objective To investigate that whether the immuno-modulatory capacity is intact in myelodysplastic syndrome-refractory anemia (MDS-RA) derived mesenchymal stem cell (MSCs) and what are the differences compare with those from normal donors.Methods Isolating MSC from MDS and normal donors respectively and exam their differences on T lymphocyte activation,proliferation and suppression.Results The results showed that the capacity of suppressing T cell proliferation and activation is weakened.Conclusion We propose that MSCs from pathological environment might be abnormal and should not be used for autologous transplantation.