Meian granule in treatment of melasma: a clinical trial
10.3760/cma.j.issn.1671-0290.2012.04.011
- VernacularTitle:美安颗粒治疗黄褐斑的效果观察
- Author:
Yang LIU
;
Zhen ZHANG
;
Jinan CHEN
;
Xiangdong CHEN
- Publication Type:Journal Article
- Keywords:
Melasma;
Meian granule;
Therapeutic effects
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2012;18(4):273-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of Meian granule in the treatment of patients with melasma and to investigate the recurrence rate.Methods The patients,who were diag nosed pathologically as melasma from November 2010 to April 2011 in our department and accorded with the standards that we supposed,were enrolled in this study.They were then divided into three groups:Meian granule group (group A),Meian granule group (group B) and control group (group C).Patients in group A were given a packet of Meian granule each time,once a day,and those in group B were given a packet of Meian granule each time,twice a day for 2 months.Patients in group C were treated by Antixin (3 pills,thrice a day).The efficacy and safety were observed and analyzed by using statistical methods after the treatment.All the cases were followed up for a month at out-patient department or by telephone.Results A total of 158 cases of melasma were treated,including 54 cases in group A,51 cases in group B,and 53 cases in group C. The effective rates were 58 ％,52 ％,and 60 ％ in groups A,B and C,respectively.There was no significantly statistical difference (P＞0.05) of effective rates amoung the three groups.One month after the treatment the recurrence rates were 3.3 ％,15.3 ％,and 10.0 ％ in the groups A,B and C,respectively.The incidence of adverse reactions during the study were 14.8 ％,15.6 ％,and 7.5 ％,respectively.Conclusions It has been proved that Meian granule is an effective and reliable treatment for melasma.
