Expression of nuclear factor-kappa B and zinc finger protein A20 in keloid
10.3760/cma.j.issn.1671-0290.2012.04.014
- VernacularTitle:核转录因子-κB与锌指蛋白A20在瘢痕疙瘩的表达
- Author:
Lili GUO
;
Linbo LIU
- Publication Type:Journal Article
- Keywords:
Keloid;
Nuclear factor-kappa B (NF-κB);
Zinc finger protein A20
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2012;18(4):286-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protein and mRNA expression of NF-κB and zinc finger protein A20 in the keloid and normal skin and to explore its underlying molecular biological mechanism.Methods The protein and mRNA expression of NF-κB p65 and zinc finger protein A20 in keloid and normal skin was detected by immunohistochemistry and real time quantitative reverse transcription-polymerase chain reaction (RT-PCR).Results The protein and mRNA expression of NF-κB p65 in keloid tissues was higher than those in normal skin tissues (P<0.05).The protein and mRNA expression of zinc finger protein A20 in keloid tissues was lower than those in normal skin tissues (P<0.05).Conclusions NF-κB signal pathways and zinc finger protein A20 could play a role in keloid pathogenesis.