Anemia aggravates clinical and pathological changes in patients with IgA nephropathy

VernacularTitle:贫血加重IgA肾病患者的临床和病理改变
Author: Ting HE ; Haiping MAO ; Zhibin LI ; Na GUO ; Ricong XU ; Xiao YANG ; Xueqing YU ; Zhijian LI
Publication Type:Journal Article
Keywords: IgA nephropathy; Anemia; Pathology; Clinic
From: Chinese Journal of Nephrology 2012;28(6):460-463
CountryChina
Language:Chinese
Abstract: Objective To analyze the changes of clinical and pathological features in the patients of IgA nephropathy with anemia.Methods Four hundred and nine patients of IgA nephropathy diagnosed by renal biopsy were classified into two groups:IgA nephropathy with nonanemia (group 1) and IgA nephropathy with anemia (group 2).Changes were studied retrospectively between the groups.Results Serum hemoglobin level was correlated with the clinical parameters of IgA nephropathy.Companed to group 1,changes in group 2 were as followed:serum creatinine increased,eGFR decreased,proteinuria increased; the global sclerosis,segmental sclerosis,crescents and tubulointerstitial lesions worsened.The glomerular and tubulointerstitial lesions were negatively correlated with serum hemoglobin and eGFR,but positively correlated with serum uric acid and proteinuria (P＜0.05).Multivariate Logistic regression analysis revealed that anemia was an independent risk factor for the tubulointerstitial lesion.Conclusion Clinical feature and pathological damages in the patients of IgA nephropathy with anemia are more serious than those with non-anemia.