The therapeutic efficiency of hyperbaric oxygen after traumatic brain injury
10.3760/cma.j.issn.0254-1424.2012.07.010
- VernacularTitle:高压氧治疗对中重型颅脑损伤患者血清白介素-1β和白介素-6的影响及疗效分析
- Author:
Shuiping WANG
;
Zhen TAO
;
Xianan SHAO
;
Yiqun WANG
;
Shiquan YANG
;
Tian XIA
;
Bensong YU
;
Yilong QI
;
Jincheng CHENG
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Traumatic brain injury;
Interleukin-1β;
Interleukin-6;
Glasgow coma scale;
Glasgow outcome scale
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2012;34(7):520-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyperbaric oxygen (HBO) therapy on interleukin-1 β( IL-1 β) and interleukin-6 ( IL-6 ) levels in patients with moderate or severe traumatic brain injury ( TBI ) and to analyze its therapeutic efficacy.MethodsOne hundred and fifty-six patients with moderate or severe TBI were randomly divided into a control group and an HBO adjunctive therapy group with 78 cases in each.The control group received essential neurosurgical treatment and conventional drug treatment,and the HBO group was given one HBO therapy session in addition.IL-1 β and IL-6 were quantitatively determined using sandwich ELISA,and the patients'scores on the Glasgow coma scale (GCS) were measured before and after treatment.The Glasgow outcome scale (GOS) was used to evaluate in a follow-up 6 months after injury.ResultsThe average IL-1 β and IL-6 levels of the two groups and their average GCS scores were not significantly different before treatment.After treatment,IL-1 βand IL-6 levels decreased significantly and GCS scores increased significantly in both groups,but there were significant inter-group differences in all three measures.Six months after injury the GOS evaluation indicated that significantly more patients had better outcomes in the HBO group than in the control group. Conclusion Conventional treatment combined with HBO therapy can promote neurofunction recovery in TBI patients.The mechanism may be related to down-regulation of serum IL-1 β and IL-6.
