Clinicopathologic characteristics and prognosis of young non.mall cell lung cancer patients

VernacularTitle:青年人非小细胞肺癌的临床病理特征及预后研究进展
Author: Lili QU ; Xiaoqing LIU
Publication Type:Journal Article
Keywords: Young adult; Carcinoma,non-small-cell lung; Pathilogy,clincal; Prognosis
From: Cancer Research and Clinic 2012;24(6):427-430
CountryChina
Language:Chinese
Abstract: The morbidity of young non-small cell lung cancer(NSCLC)increases in the recent years.Young group patients should be defined as age under 40 years old.The risk factors of etiology in the young NSCLC may be related with smoking,genetic predisposition,Internal and external environment factors havoc and etc.There is no specific symptoms of young NSCLC,therefor,it happens misdiagnosis and harder to be confirmed.The morbidity in young female group of NSCLC patients is higher than aged patients.The most frequent histopathologic type is adenocarcinoma and the ratio of advanced stages with low differentiation has been found to be more common.The chances of surgery seems lower than others.EGFR gene mutation percentage in the young NSCLC maybe lower than that in the old patients,while the positive mutation of MEL4-ALK gene maybe more prevalent in the young patients.The prognosis of young NSCLC seems to be poor with lower tumor progression time of the first line therapy.Better prognosis of young NSCLC patients maybe achieved by early diagnosis and efficient therapy according to the accurate genotypes.