Biological characteristics of colorectal adenoma with chicken-skin mucosa and its clinical significance
10.3760/cma.j.issn.1007-5232.2012.06.012
- VernacularTitle:成人大肠腺瘤伴鸡皮样黏膜改变的临床意义
- Author:
Jingming GUAN
;
Chunming LI
;
Xueyan ZHANG
;
Yudong GUO
;
Xiao MA
- Publication Type:Journal Article
- Keywords:
Adenoma,coion;
Neoplasia;
Cell proliferation;
Apoptosis;
Chicken-skin mucosa
- From:
Chinese Journal of Digestive Endoscopy
2012;29(6):336-340
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the biological features of colorectal adenoma with chicken-skin mucosa ( CSM ) and its clinical significance.MethodsExpression of cell proliferation markers ( Ki-67 and COX-2) and apoptosis-related factors ( survivin and caspase-3) in normal colorectal mucosa,colorectal adenoma without CSM,colorectal adenoma with CSM and colorectal adenocarcinoma were detected by immunohistochemistry SP method and enzyme-linked immunosorbent assay (ELISA).ResultsImmunohistochemical results revealed a decreased trend in expressions of Ki-67 and COX-2 from colorectal adenocarcinoma through colorectal adenoma with and without CSM to normal colorectal mucosa,while the expressions of survivin and caspase-3 showed an increased trend.By ELISA,the expressions of Ki-67,COX-2,surviving and caspase-3 showed no significant difference (P ＞ 0.05 ) between colorectal adenoma with CSM and coloreetal adenocarcima,while these variables were significantly different (P ＜ 0.05) between coloreetal adenoma with and without CSM,so as well between normal colorectal mucosa and other 3 groups.ConclusionThe biological characteristics of colorectal adenoma with CSM are different from those without,showing an activated cell proliferation and inhibited cell apoptosis with increased carcinogenesis risk.
