Immunohistochemical Demonstration of Nerve Fibers of the Human Knee Synovium.
- Author:
Yeung Jin KIM
1
;
Tae Kyun KIM
;
Hwan Deok YANG
;
Hyung Joon KIM
;
Hyang Jung CHO
;
Dae Han WIE
;
Ji Wan LEE
Author Information
1. Department of Orthopaedics Surgery, College of Medicine, Wonkwang University Hospital. yjkim1@wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Knee;
Synovium;
Immunohistochemistry
- MeSH:
Antibodies;
Cadaver;
Calcitonin Gene-Related Peptide;
Humans*;
Immunohistochemistry;
Knee Joint;
Knee*;
Nerve Endings;
Nerve Fibers*;
Substance P;
Synovial Membrane*
- From:Journal of Korean Orthopaedic Research Society
2007;10(1):10-15
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To demonstrate the presence of nerve fibers including nociceptive fibers in synovium of human knee joint using immunohistochemistry. MATERIALS AND METHODS: 10 Synovial membrane tissues of knee joint obtained from 5 cadavers were analyzed immunohistochemically using antibodies to protein gene product 9.5, betaIII-tubulin, substance P and calcitonin gene-related peptide (CGRP). RESULTS: Many nerve fibers immunoreactive for protein gene product 9.5 and betaIII-tubulin were demonstrated in synovial folds of human knee joints. Also, immunostaining showed the presence of free nerve ending fibers immunoreactive for substance P and calcitonin gene-related peptide in synovium. CONCLUSION: The presence of putative nerve fibers including nociceptive fibers in synovial folds supports a possible role for theses structures as source of knee joint pain.
