H-magnetic resonance spectrum of putaman of Tourette' s syndrome
10.3760/cma.j.issn.1006-7876.2012.06.008
- VernacularTitle:图雷特综合征患者双侧壳核的磁共振氢质子波谱特点
- Author:
Bo YANG
;
Guiping LI
;
Jinshan ZHANG
;
Xiangquan KONG
;
Haibo XU
;
Lin MA
;
Huiyi YE
;
Youquan CAI
;
Yuangui GAO
- Publication Type:Journal Article
- Keywords:
Tourette syndrome;
Putamen;
Magnetic resonance spectroscopy
- From:
Chinese Journal of Neurology
2012;45(6):392-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of the putamen metabolites with magnetic resonance spectrum(MRS),and to explore possible underlying unrecongnised aetiological factor and pathophysiology mechanism in the central nervous system of the patients with Tourette' s syndrome.Methods Twenty-two cases of Tourette' s syndrome,and twenty-two gender and age-matched subjects ( the control subjects ) were performed on a clinical 3.0 T MRI system.Proton prob-voxel spectroscopy imaging (1H-MRS) was obtained from two sides of the putamen.The metabolites included N-acetylaspartate (NAA),creatine and phosphocreatine ( Cr),choline-containing compounds (Cho),and myoinositol ( MI ).The value of the NAA,Cr,Cho,and MI were calculated by integration of their peaks.The ratios of NAA/Cr,Cho/Cr,ML/Cr were calculated respectively.Repeated measures analysis of variance ( ANOVA ) was used to test both the value of NAA/Cr,Cho/Cr,MI/Cr of the putamen for group difference,with group as between-subjects factor and side as within-subjects factor.Results The NAA/Cr ratio in patients ( left:1.29 ± 0.13 ; right:1.34 + 0.15 ) was significantly lower than that in the control subjects ( left:1.50 ± 0.08,T =1.962,P ＜0.05 ; right:1.52 ± 0.11,T =1.865,P ＜ 0.05 ).There was no significant difference in the Cho/Cr and MI/Cr ratio between both groups.Conclusion The abnormalities of the structure and(or) function in the putamens of patients may be the one of the underlying anaetiological factors and pathophysiology mechanisms of the Tourette' s syndrome.
